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1994-10-25
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Document 3075
DOCN M94A3075
TI HIV incidence in adults in northern Thailand.
DT 9412
AU Khamboonruang C; Beyrer C; Natpatan C; Eiumtrakol S; Celentano D; Nelson
KE; Research Institute for Health Sciences, Chiang Mai University,;
Thailand.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):16 (abstract no. 038C). Unique
Identifier : AIDSLINE ICA10/94369500
AB OBJECTIVE: To measure the HIV-1 incidence, followup rates and high risk
behaviors in cohorts of seronegative adults in northern Thailand.
METHODS: We screened cohorts of female commercial sex workers (CSWs),
male STD clinic pts, royal Thai Army (RTA) conscripts, and discharged
RTA conscripts at baseline and q3-6 mos. for HIV infection by ELISA and
WB and did interviews for high risk behavior, medical history, and STD
cultures. RESULTS: Of 1068 CSWs 409 (38.3%) were HIV pos and 396 HIV neg
were enrolled in the study; followup at 6 mos. was 70.7% and 19
seroconverted for an incidence of 12.8/100 person yrs. Of 1031 male STD
pts 164(15.9%) were HIV pos and 264 HIV neg (30.4%) were enrolled;
followup at 6 mos was 91.9% and 6 seroconverted for an incidence of
4.92/100 person yrs. Of 969 RTA conscripts 12.4% were HIV pos at
baseline and 90% were followed at 6 mos; 3 of 778 seroconverted an
incidence of 0.87/100 person yrs. (Previous RTA cohorts have had an
incidence of 3.4%/yr.) Among 380 men discharged from RTA, followup at 9
mos. was 81.8% and the incidence was 5.2/100 person yrs. Sample sizes
required to show an HIV vaccine efficacy of 60%, with a power = .90,
alpha = .05 varies from CSWs = 644, STD pts. 1,456 to ex-RTA = 1306.
CONCLUSIONS: Several populations in northern Thailand appear to have
sufficiently high HIV-1 incidence and adequate followup for HIV vaccine
efficacy trials and other preventive intervention trials.
DE Adult Blotting, Western Enzyme-Linked Immunosorbent Assay Female
Human HIV Infections/*EPIDEMIOLOGY/PREVENTION & CONTROL/TRANSMISSION
HIV Seropositivity/EPIDEMIOLOGY *HIV-1 Male Military Personnel
Prostitution Risk-Taking Sex Behavior Sexually Transmitted
Diseases/EPIDEMIOLOGY Thailand/EPIDEMIOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).